Cervós-Navarro “Enhancement of nerve fibre regeneration by nucleotides after peripheral nerve crush damage” Electrophysiologic and morphometric investigations. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation” Fortschr Med, Vol. Hasse, “Medicamentous therapy of alcoholic polyneuropathy. Randomized and blind study” Rev Med Chil, Vol. Verdugo, “Effect of the Nucleus CMP forte in 46 patients with progressive spastic paraparesis. Del Gatto, “Effects of uridine in the treatment of diabetic neuropathy: an electrophysiological study”ActaNeurol Scand, Vol. Schulz, “Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease” ToxicolLett, Vol. Stricker, “Animal models of parkinsonism using selective neurotoxins: clinical and basic implications” Int Rev Neurobiol, Vol. Bhavnani, “Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens” BMC Neurosci, Vol.7, 2006,pp. Choi, “Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death” Neuron, Vol. Garthwaita, “Excitatory amino acid neurotoxicity and neurodegenerative disease” Trends PharmacolSci, Vol. Olney, “Excitotoxicity and the NMDA receptor-still lethal after eight years” Trends Neurosci, Vol. Lyeth, “Neurotransmitter-mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids” J TraumaSuppl, Vol. Rothman, “The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death” Neurosci, Vol. These results indicate that the nucleotides included in Nucleo CMP Forte ® are promising therapeutic molecules for the prevention of neuronal death in brain caused by focal ischemia, Parkinson’s disease or other neurodegenerative pathologies.ĭ.W. More interestingly, drug pre-treatment significantly reduced MPP +- and glutamate-induced cell death in SH-SY5Y cells and in rat cortical cells. Nucleo CMP Forte ® pre-treatment significantly increased the rate of cell division in SH-SY5Y cells, as well as the synthesis of triglycerides and phospholipids. Cell viability was measured at different times. We used the human dopaminergic cell line SH-SY5Y and a primary culture of rat cortical cells pre-treated with the drug for 24 hours and then exposed to MPP + or glutamate at a range of concentrations. We examined its neuroprotective effects on cell toxicity induced by glutamate excitotoxicity or by 1-methyl-4-phenyl-pyridinium (MPP +), an in vitro cell model of Parkinson’s disease. Its effects on brain pathologies has re-ceived little attention. It has been prescribed for peripheral nervous system disorders, such as lum-bosciatalgia, diabetic or alcoholic polyneuropathy, or trigeminal neuralgia. Nucleo CMP Forte ® is a nucleotide-based drug consisting of cytidinemonophosphate, uridinemonophosphate, uridin-ediphosphate and uridinetriphosphate.
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